Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration
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چکیده
منابع مشابه
Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb
Although the role of noxious α-synuclein (α-SYN) in the degeneration of midbrain dopaminergic neurons and associated motor deficits of Parkinson's disease is recognized, its impact on non-motor brain circuits and related symptoms remains elusive. Through combining in vivo two-photon imaging with time-coded labelling of neurons in the olfactory bulb of A30P α-SYN transgenic mice, we show impaire...
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Tauopathic pathways lead to degenerative changes in Alzheimer's disease and there is evidence that they are also involved in the neurodegenerative pathology of Parkinson's disease [PD]. We have examined tauopathic changes in striatum of the α-synuclein (α-Syn) A53T mutant mouse. Elevated levels of α-Syn were observed in striatum of the adult A53T α-Syn mice. This was accompanied by increases in...
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Fibrillar accumulation of A53T mutant α-synuclein (A53T-AS) in Lewy bodies is a symptom of Parkinsonism. Inhibitions of the overexpression and fibrillar aggregation of α-synuclein (AS) in vivo could be a promising strategy for treating Parkinson's disease (PD). In this study, at concentrations lower than 1 mM, trehalose decreased the A53T-AS expression level in transduced PC12 cells. Although H...
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Department of Physiology, Faculty of Medicine, University of Szeged, 6720, Szeged, Hungary; National Psychiatry Center, Semmelweis University, 1083 Budapest, Hungary; Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102; Stress and Motivated Behavior Institute, Veterans Affairs Medical Center, New Jersey Health Care System, East Orange, NJ 07018; and Department...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.561963